13,844 research outputs found
JPL's electric and hybrid vehicles project: Project activities and preliminary test results
Efforts to achieve a 100 mile urban range, to reduce petroleum usage 40% to 70%, and to commercialize battery technology are discussed with emphasis on an all plastic body, four passenger car that is flywheel assisted and battery powered, and on an all metal body, four passenger car with front wheel drive and front motor. For the near term case, a parallel hybrid in which the electric motor and the internal combustion engine may directly power the drive wheels, is preferred to a series design. A five passenger car in which the electric motor and the gasoline engine both feed into the same transmission is discussed. Upgraded demonstration vehicles were tested using advanced lead acid, nickel zinc, nickel iron, and zinc chloride batteries to determine maximum acceleration, constant speed, and battery behavior. The near term batteries demonstrated significant improvement relative to current lead acid batteries. The increase in range was due to improved energy density, and ampere hour capacity, with relatively 1 small weight and volume differences
Methodological reflections on the evaluation of the implementation and adoption of national electronic health record systems
Copyright @ 2012, International Journal of Integrated Care (IJIC). This work is licensed under a (http://creativecommons.org/licenses/by/3.0) Creative Commons Attribution 3.0 Unported License.Introduction/purpose of presentation: Far-reaching policy commitments to information technology-centered transformations of healthcare systems have now been made in many countries. There is as yet little empirical evidence to justify such decisions, hence the need for rigorous independent evaluation of current implementation efforts. Such evaluations however pose a number of important challenges. This presentation has been designed as a part of a Panel based on our experience of evaluating the National Health Service’s (NHS) implementation of electronic health records (EHR) systems in hospitals throughout England. We discuss the methodological challenges encountered in planning and undertaking an evaluation of a program of this scale and reflect on why and how we adapted our evaluation approach—both conceptually and methodologically—in response to these challenges. Study design/population studied: Critical reflections on a multi-disciplinary and multi-facet independent evaluation of a national program to implement electronic health record systems into 12 ‘early wave’ NHS hospitals in England. Findings: Our initial plan was to employ a mixed methods longitudinal ‘before-during-after’ study design. We however found this unsustainable in the light of fluxes in policy, contractual issues and over-optimistic schedules for EHR deployments. More importantly, this research design failed adequately to address the core of multi-faceted evolving EHRs as understood by key stakeholders and as worked out in their distinct work settings. Thus conventional outcomes-centric evaluations may not easily scale-up when evaluating transformational programs and may indeed prove misleading. New assumptions concerning the implementation process of EHR need to be developed that recognize the constantly changing milieu of policy, product, projects and professions that are inherent to such national implementations. The approaches we subsequently developed substitute the positivist view that EHR initiatives are self-evident and self-contained interventions, which are amenable to traditional quantitative evaluations, to one that focuses on how they are understood by various stakeholders and made to work in specific contexts. These assumptions recast the role of evaluation towards an approach that explores and interprets processes of socio-technical change that surround EHR implementation and adoption as seen by multiple stakeholders. Conclusions and policy implications: There is likely to be an increase in politically-driven national programs of reform of healthcare based on information and communication technologies. Programs on such a scale are inherently complex with extended temporalities and extensive and dynamic sets of stakeholders. They are, in short, different and pose new evaluation challenges that previously formulated evaluation methods for health information systems cannot easily address. This calls for methodological innovation amongst research teams and their supporting bodies. We argue that evaluation of such system-wide transformation programs are likely to demand both breadth and depth of experience within a multidisciplinary research team, constant questioning of what is and what can be evaluated and how, and a particular way of working that emphasizes continuous dialogue and reflexivity. Making this transition is essential to enable evaluations that can usefully inform policy-making. Health policy experts urgently need to reassess the evaluation strategies they employ as they come to address national policies for system-wide transformation based on new electronic health infrastructures
Turbofan forced mixer lobe flow modeling. 1: Experimental and analytical assessment
A joint analytical and experimental investigation of three-dimensional flowfield development within the lobe region of turbofan forced mixer nozzles is described. The objective was to develop a method for predicting the lobe exit flowfield. In the analytical approach, a linearized inviscid aerodynamical theory was used for representing the axial and secondary flows within the three-dimensional convoluted mixer lobes and three-dimensional boundary layer analysis was applied thereafter to account for viscous effects. The experimental phase of the program employed three planar mixer lobe models having different waveform shapes and lobe heights for which detailed measurements were made of the three-dimensional velocity field and total pressure field at the lobe exit plane. Velocity data was obtained using Laser Doppler Velocimetry (LDV) and total pressure probing and hot wire anemometry were employed to define exit plane total pressure and boundary layer development. Comparison of data and analysis was performed to assess analytical model prediction accuracy. As a result of this study a planar mixed geometry analysis was developed. A principal conclusion is that the global mixer lobe flowfield is inviscid and can be predicted from an inviscid analysis and Kutta condition
Systems comparison of direct and relay link data return modes for advanced planetary missions
Advanced planetary missions using direct and relay link data return mode
Diet-induced obesity impairs mammary development and lactogenesis in murine mammary gland
We have developed a mouse model of diet-induced obesity that shows numerous abnormalities relating to mammary gland function. Animals ate 40% more calories when offered a high-fat diet and gained weight at three times the rate of controls. They exhibited reduced conception rates, increased peripartum pup mortality, and impaired lactogenesis. The impairment of lactogenesis involved lipid accumulation in the secretory epithelial cells indicative of an absence of copius milk secretion. Expression of mRNAs for -casein, whey acid protein, and -lactalbumin were all decreased immediately postpartum but recovered as lactation was established over 2–3 days. Expression of acetyl-CoA carboxylase (ACC)- mRNA was also decreased at parturition as was the total enzyme activity, although there was a compensatory increase in the proportion in the active state. By day 10 of lactation, the proportion of ACC in the active state was also decreased in obese animals, indicative of suppression of de novo fatty acid synthesis resulting from the supply of preformed fatty acids in the diet. Although obese animals consumed more calories in the nonpregnant and early pregnant states, they showed a marked depression in fat intake around day 9 of pregnancy before food intake recovered in later pregnancy. Food intake increased dramatically in both lean and obese animals during lactation although total calories consumed were identical in both groups. Thus, despite access to high-energy diets, the obese animals mobilized even more adipose tissue during lactation than their lean counterparts. Obese animals also exhibited marked abnormalities in alveolar development of the mammary gland, which may partially explain the delay in differentiation evident during lactogenesis
Optical Lattice Induced Light Shifts in an Yb Atomic Clock
We present an experimental study of the lattice induced light shifts on the
1S_0-3P_0 optical clock transition (v_clock~518 THz) in neutral ytterbium. The
``magic'' frequency, v_magic, for the 174Yb isotope was determined to be 394
799 475(35)MHz, which leads to a first order light shift uncertainty of 0.38 Hz
on the 518 THz clock transition. Also investigated were the hyperpolarizability
shifts due to the nearby 6s6p 3P_0 - 6s8p 3P_0, 6s8p 3P_2, and 6s5f 3F_2
two-photon resonances at 759.708 nm, 754.23 nm, and 764.95 nm respectively. By
tuning the lattice frequency over the two-photon resonances and measuring the
corresponding clock transition shifts, the hyperpolarizability shift was
estimated to be 170(33) mHz for a linear polarized, 50 uK deep, lattice at the
magic wavelength. In addition, we have confirmed that a circularly polarized
lattice eliminates the J=0 - J=0 two-photon resonance. These results indicate
that the differential polarizability and hyperpolarizability frequency shift
uncertainties in a Yb lattice clock could be held to well below 10^-17.Comment: Accepted to PR
Phase structure and monopoles in U(1) gauge theory
We investigate the phase structure of pure compact U(1) lattice gauge theory
in 4 dimensions with the Wilson action supplemented by a monopole term. To
overcome the suppression of transitions between the phases in the simulations
we make the monopole coupling a dynamical variable. We determine the phase
diagram and find that the strength of the first order transition decreases with
increasing weight of the monopole term, the transition thus ultimately getting
of second order. After outlining the appropriate topological characterization
of networks of currents lines, we present an analysis of the occurring monopole
currents which shows that the phases are related to topological properties.Comment: 22 pages (latex), 14 figures (available upon request), BU-HEP 94-
Quasiperiodic spin-orbit motion and spin tunes in storage rings
We present an in-depth analysis of the concept of spin precession frequency
for integrable orbital motion in storage rings. Spin motion on the periodic
closed orbit of a storage ring can be analyzed in terms of the Floquet theorem
for equations of motion with periodic parameters and a spin precession
frequency emerges in a Floquet exponent as an additional frequency of the
system. To define a spin precession frequency on nonperiodic synchro-betatron
orbits we exploit the important concept of quasiperiodicity. This allows a
generalization of the Floquet theorem so that a spin precession frequency can
be defined in this case too. This frequency appears in a Floquet-like exponent
as an additional frequency in the system in analogy with the case of motion on
the closed orbit. These circumstances lead naturally to the definition of the
uniform precession rate and a definition of spin tune. A spin tune is a uniform
precession rate obtained when certain conditions are fulfilled. Having defined
spin tune we define spin-orbit resonance on synchro--betatron orbits and
examine its consequences. We give conditions for the existence of uniform
precession rates and spin tunes (e.g. where small divisors are controlled by
applying a Diophantine condition) and illustrate the various aspects of our
description with several examples. The formalism also suggests the use of
spectral analysis to ``measure'' spin tune during computer simulations of spin
motion on synchro-betatron orbits.Comment: 62 pages, 1 figure. A slight extension of the published versio
Frequency evaluation of the doubly forbidden transition in bosonic Yb
We report an uncertainty evaluation of an optical lattice clock based on the
transition in the bosonic isotope Yb by use
of magnetically induced spectroscopy. The absolute frequency of the
transition has been determined through comparisons
with optical and microwave standards at NIST. The weighted mean of the
evaluations is (Yb)=518 294 025 309 217.8(0.9) Hz. The uncertainty
due to systematic effects has been reduced to less than 0.8 Hz, which
represents in fractional frequency.Comment: 4 pages, 3 figure -Submitted to PRA Rapid Communication
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